Isavuconazonium sulfate

Research use only, not for human use.

Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole.

Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), which catalyzes the demethylation of lanosterol to yield ergosterol, an important component of the fungal cell membrane. Isavuconazonium Sulfate is a prodrug of the triazole antifungal agent isavuconazole, with broad-spectrum antifungal activity. Inhibition of CYP51 leads to a decrease in fungal ergosterol production and disrupts the synthesis of the fungal cell membrane, which decreases membrane integrity, increases cell membrane permeability and promotes the loss of essential intracellular elements. This results in fungal cell lysis and death.

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Animal Model:Neutropenic male ICR mouse model of intratracheal infection Dosage:215 mg/kg Administration:Oral gavage (p.o.); Three times a day for 4 days.Result:Increased the survival rate of neutropenic mice infected with R. delemar.Reduced fungal load in the lungs and brains of mice.

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Microbiology/Virology

Antifection

inhibits the synthesis of ergosterol| lanosterol 15 alpha-demethylase inhibitor

Infection

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946075-13-4

814.84

C35H36F2N8O9S2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (122.72 mM)

n1(nc[n+](c1)C(C)OC(=O)N(c1c(cccn1)COC(=O)CNC)C)C[C@]([C@@H](C)c1scc(n1)c1ccc(cc1)C#N)(O)c1c(ccc(c1)F)F.S(=O)(=O)(O)[O-]

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(-20℃)

With Ice Pack

≥ 2 years